Updated: Mar 17
The previous article discussed how the liver sends nutrients into general circulation throughout the body for various purposes, such as energy production, building the body's components, storage, and excretion. In this article, we will focus on how energy is produced and transferred within the body.
Energy is not created or destroyed but rather transformed or moved according to the laws of thermodynamics. Instead of making energy, our bodies convert the energy stored within our food by breaking down the chemical bonds that hold its molecules together. This process is called energy transfer and is used to form ATP, which is the body's "energy currency" required for nearly every action in the body. We can get ATP from recently absorbed nutrients or stored nutrients, such as triglycerides and glycogen. These raw materials are stored in one form and used in another, often different from the form in which they were consumed. For instance, a meal containing beans and avocado guacamole gets broken down into glucose, amino acids, short-chain fatty acids, and triglycerides that no longer resemble their original forms. Think of ATP as a tiny battery that powers everything in your body. It's made up of a molecule called adenosine and three phosphate molecules. When the bonds between these molecules are broken, energy is released. However, our bodies only store a small amount of ATP, so we need to constantly regenerate it to keep our energy levels up. This is where energy transfer comes in. Our body can create ATP in different ways, depending on what nutrients are available, how fast we need the energy, and whether there's enough oxygen around. There are three main processes that help create ATP: 1- the ATP-PCr system 2- the glycolytic pathway 3- the oxidative phosphorylative pathway. So, even though ATP is a tiny molecule, it plays a huge role in keeping us energized! The ATP-PCr system is the quickest way for our bodies to produce ATP, the energy currency of our cells. It stands for Adenosine Triphosphate - Phosphocreatine system and is used for short bursts of high-intensity exercises, such as sprinting or weightlifting.
The ATP-PCr system works by breaking down phosphocreatine (PCr) in the muscles to create ATP. The PCr molecule donates a phosphate group to ADP (Adenosine Diphosphate), which creates ATP. This process is extremely fast and doesn't require oxygen, which makes it ideal for intense, anaerobic exercise.
However, there's a catch: our body's stores of PCr are limited, and they can only supply energy for about 10 seconds of maximal effort. After that, our body has to turn to other energy systems to keep going.
The ATP-PCr system is important for athletes who rely on short, intense bursts of energy, such as sprinters, jumpers, and weightlifters. By training their bodies to improve their ATP-PCr system, these athletes can improve their explosive power and speed.
To improve the ATP-PCr system, athletes can do exercises that involve short, intense bursts of energy, such as sprinting or jumping. They can also use supplements like creatine, which can increase the amount of PCr stored in the muscles and improve ATP production.
In conclusion, the ATP-PCr system is a crucial energy system for short, intense bursts of exercise. While its energy supply is limited, athletes can improve their performance in these types of activities by training their bodies to use this system more efficiently. The glycolytic pathway is another process through which our body can produce ATP, particularly in situations where we need a quick burst of energy. This pathway breaks down glucose, a type of sugar, to produce ATP.
The glycolytic pathway can be divided into two phases: the energy investment phase and the energy payoff phase. In the energy investment phase, two molecules of ATP are used to activate glucose, which is then split into two smaller molecules called pyruvate. In the energy payoff phase, four molecules of ATP are produced by breaking down pyruvate.
The glycolytic pathway is particularly important for high-intensity activities that last between 30 seconds to two minutes, such as sprinting or weightlifting. During these activities, the demand for energy is high and the body can quickly produce ATP through the glycolytic pathway.
However, there are limitations to the glycolytic pathway. One is that it produces ATP at a relatively slow rate compared to the ATP-PCr system. Additionally, the pathway produces lactic acid as a byproduct, which can build up in muscles and cause fatigue and discomfort.
Despite these limitations, the glycolytic pathway is an important process in our body's energy production. It allows us to quickly generate ATP during high-intensity activities, and with training, we can even improve our body's ability to use this pathway efficiently. The oxidative phosphorylation pathway is the most complex of the three energy transfer systems in our body. It is a series of chemical reactions that occur in the mitochondria of cells and involves the use of oxygen to generate ATP.
During the oxidative phosphorylation pathway, energy-rich molecules like glucose and fatty acids are broken down into smaller molecules, releasing energy in the process. This energy is then used to generate ATP molecules.
The pathway is divided into five major steps, each with its own set of enzymes and cofactors. These steps include:
Glycolysis: This is the same process as in the glycolytic pathway, where glucose is converted into pyruvate in the cytoplasm of the cell, releasing a small amount of ATP and NADH.
Pyruvate oxidation: The pyruvate produced in glycolysis is transported into the mitochondria, where it is converted into acetyl-CoA. This process produces NADH.
Krebs cycle (also called the citric acid cycle): Acetyl-CoA enters the Krebs cycle, where it is broken down into carbon dioxide, producing more ATP, NADH, and FADH2.
Electron transport chain: This is where most of the ATP is generated. NADH and FADH2 produced in the previous steps donate electrons to the electron transport chain, which pumps protons across the inner mitochondrial membrane, creating an electrochemical gradient. The flow of protons back across the membrane through ATP synthase generates ATP.
Oxidative phosphorylation: The final step in the pathway involves the transfer of electrons from the electron transport chain to oxygen, which creates water and releases more energy for ATP synthesis.
The oxidative phosphorylation pathway is highly efficient and can generate up to 36 ATP molecules per glucose molecule. It is the primary energy pathway used during prolonged exercise and other activities that require sustained energy production.
However, it is important to note that this pathway requires oxygen to function, and can only generate energy aerobically. Therefore, during intense exercise or in conditions of oxygen deprivation, the body must rely on the other two energy transfer systems to produce ATP. All three energy systems work together to supply energy to our body, but they differ in terms of the speed and duration of energy production, as well as the type of fuel used. The ATP-PCr system is the fastest but can only sustain high-intensity activities for a short period. The glycolytic pathway is slightly slower but can provide energy for a longer duration, while the oxidative phosphorylative pathway is the slowest but can generate energy for hours.
During high-intensity activities, the body relies primarily on the ATP-PCr system for energy. As the duration of the activity increases, the glycolytic pathway becomes the dominant energy system. The oxidative phosphorylative pathway is the primary energy system for endurance activities such as long-distance running or cycling.
It's important to note that energy systems are not mutually exclusive, and they work together to support our body's energy needs. The efficiency of each energy system is dependent on a variety of factors, including nutrition, hydration, and training.
In conclusion, understanding how our body generates energy is crucial for optimizing our performance during physical activity. Whether we're sprinting, lifting weights, or running a marathon, our body relies on a combination of energy systems to supply the fuel needed to power our muscles. By training and fueling our bodies appropriately, we can enhance our energy systems' efficiency and maximize our physical performance. In the next article, we will talk about metabolization in Decoding the Pathways of Human Metabolism: How Our Body Converts Nutrients into Energy.